ORGLIST: Nitration...

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From: Antonello Mai and Gianluca Sbardella (r.ragno$##$caspur.it)
Date: Wed Apr 08 1998 - 04:15:31 EDT


Dear colleagues,
A few days ago I tryed to nitrate ethyl benzoylacetate (PhCOCH2COOEt) but
all my attempts were unsuccessful: in fact both HNO3/H2SO4 mixture and
HNO3/acetic anhydride mixture (at various temperatures) yelded the
demolition of beta-ketoester chain. Did any of you ever try something
similar (any suggestion would be appreciate)?

Moreover, I need to nitrate a quinolone ring. Do you have any suggestion
(again...)?

Thank you very much in advance.

Gianluca "Merlino" Sbardella


    ***************************************************************
    * *
    * Dr. Antonello Mai, Ph.D. Dr. Gianluca Sbardella, Ph.D. *
    * "The Wizard of Oz" "Merlino" *
    * *
    * Dip. Studi Farmaceutici E-mail: r.ragno$##$caspur.it *
    * Universita' "La Sapienza" Phone: 39-6-49913814 *
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    * ITALY *
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    * "Il destino e' quel che e', non c'e' scampo piu' per me.." *
    * (Gene Wilder, "Frankenstein Junior") *
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    * "Destiny, destiny, no escaping that for me..." *
    * (Gene Wilder, "Young Frankenstein") *
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