RE: ORGLIST: MOM group stability

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From: will jones (willjones46$##$hotmail.com)
Date: Mon Oct 24 2005 - 17:14:04 EDT


Both groups you have mentioned are stable up to pH 12. You can therefore
hydrolyse in the presence of NaOH provided that you dont heat too much and
the pH isnt above 12. You can usually use a 1:1 dioxane:water/NaOH to effect
ester hydrolysis.

Will


>From: "morthala raghavendar rao" <raghumorthala$##$rediffmail.com>
>Reply-To: morthala raghavendar rao <raghumorthala$##$rediffmail.com>
>To: everybody$##$orglist.net
>Subject: ORGLIST: MOM group stability
>Date: 23 Oct 2005 21:43:27 -0000
>
>  
>Hi there,
>
>I am doing one reaction wherein I need to hydrolyse ester group of N-MOM
>and BOC protected amino acid using NaOH. Is any one know whether the MOM
>group is stable with NaOH/ethanol reflux or not. If it is not stable could
>you tell me which method is suitable for this hydrolysis without affecting
>MOM group.
>
>Thanks
>Raghavendar Rao
>


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